Browsing by Author "Sello, M"

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    Antimicrobial wound healing properties of indigenous medicinal plants of Lesotho and the pharmacist's role in minor wound care
    (Department of Pharmacy, National University of Lesotho, Lesotho, 2021) Hlokoane, OK; Sello, M
    Lesotho has a rich supply of indigenous medicinal plant resources. More than a dozen Lesotho medicinal plants have been used to treat minor wound infections among Basotho for over 100 years. The aim is to provide scientific validation of their antimicrobial activities against microorganisms relevant to the skin. The anti-infective activities of plants are thought to be due to the presence of active phytochemicals in parts of the plants, especially phenolic compounds, anthraquinones, glycosides, and alkaloids. Although there is limited research that establishes the structure-activity relationship of those phytochemicals, there are reports that attributed the phytochemical constituents with the antimicrobial effects through a variety of mechanisms ranging from inhibition of cytoplasmic membrane function, inhibition of energy metabolism to inhibition of bacterial nucleic acid synthesis. The role of the pharmacist is to provide medical information on these compounds to promote the safe use of herbal products and in combination with conventional medicines.
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    HIV Self-Testing in Southern Africa: Progress and Challenges
    (International Journal of Recent Innovations in Medicine and Clinical Research, 2019-12-29) Sello, M; Ramathebane, Maseabata M; Maja, L.J; Shelile, M.Z; Namole, L.D
    Pitfalls of HIV testing in health care facilities include fears over loss of privacy and confidentiality. HIV self-testing represents an innovative strategy to expand access to HIV testing services in the general population and also to reach individuals at high risk for HIV who may not otherwise submit to HIV testing, including young people and key populations. We conducted a systematic review of observational studies done in southern African countries between the 1st January 2016 to 15th March 2018 on HIVST with focus on progress made and challenges observed. Thirteen (13) observational studies satisfied the inclusion criteria. These studies were published between January 2016 and March 2018 across five southern African countries namely Zambia (3), Malawi (2), South Africa (5), Zimbabwe (1), Botswana (1). There was also a study done in both Malawi and Zimbabwe (1). HIVST is highly acceptable in southern Africa despite challenges ranging from gender differences, acquisition of test kits, lack of pre-test and post-test counseling, potential social harm and inadequate ability to following user’s instructions
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    HIV Self-Testing in Southern Africa: Progress and Challenges
    (International Journal of Recent Innovations in Medicine and Clinical Research, 2019-12-02) Sello, M; Ramathebane, M.V; Maja, L,J; Shelile, M,Z; Namole, L, D
    Pitfalls of HIV testing in health care facilities include fears over loss of privacy and confidentiality. HIV self-testing represents an innovative strategy to expand access to HIV testing services in the general population and also to reach individuals at high risk for HIV who may not otherwise submit to HIV testing, including young people and key populations. We conducted a systematic review of observational studies done in southern African countries between the 1st January 2016 to 15th March 2018 on HIVST with focus on progress made and challenges observed. Thirteen (13) observational studies satisfied the inclusion criteria. These studies were published between January 2016 and March 2018 across five southern African countries namely Zambia (3), Malawi (2), South Africa (5), Zimbabwe (1), Botswana (1). There was also a study done in both Malawi and Zimbabwe (1). HIVST is highly acceptable in southern Africa despite challenges ranging from gender differences, acquisition of test kits, lack of pre-test and post-test counseling, potential social harm and inadequate ability to following user’s instructions.