Evaluation of Southern African Wild Edible Plants for Potential Herb-Drug Interactions Through Ex Vivo P-Glycoprotein and In Vitro Cytochrome P450 3A4 Inhibitory Effects
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Date
2024-11-08
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Wild edible plants (WEPs) including herbs provide staple foods as well as
income for local communities on the African continent. However, these commonly used plant
materials interact with orthodox or conventional drugs through both p-glycoprotein (P-gp)
and cytochrome P450 enzymes inhibition. Hence, it is vital to explore the possibility of herb-
drug interactions when concomitantly taking conventional drug dosage forms with some of
the WEPs. P-gp and CYP3A4 show analogous substrate specificities and work together to
establish an intestinal absorption barrier against xenobiotics. This study investigated the ex
vivo p-glycoprotein inhibition and the in vitro inhibition of cytochrome P450 3A4 (CYP3A4)
isoezyme by selected wild edible plants to identify potential food/herb-drug interactions.
Description
Keywords
p-glycoprotein, cytochrome P450 3A4 isoenzyme, microsomes, porcine intestinal tissue, wild edible plants