Evaluation of Southern African Wild Edible Plants for Potential Herb-Drug Interactions Through Ex Vivo P-Glycoprotein and In Vitro Cytochrome P450 3A4 Inhibitory Effects

dc.contributor.authorKheoane, P S
dc.contributor.authorMokhetho, K C
dc.contributor.authorMokhele, S
dc.contributor.authorMbara, K C
dc.contributor.authorLeonard, C M
dc.contributor.authorGadaga, T H
dc.contributor.authorTarirai, C
dc.date.accessioned2024-11-15T10:06:13Z
dc.date.available2024-11-15T10:06:13Z
dc.date.issued2024-11-08
dc.description.abstractWild edible plants (WEPs) including herbs provide staple foods as well as income for local communities on the African continent. However, these commonly used plant materials interact with orthodox or conventional drugs through both p-glycoprotein (P-gp) and cytochrome P450 enzymes inhibition. Hence, it is vital to explore the possibility of herb- drug interactions when concomitantly taking conventional drug dosage forms with some of the WEPs. P-gp and CYP3A4 show analogous substrate specificities and work together to establish an intestinal absorption barrier against xenobiotics. This study investigated the ex vivo p-glycoprotein inhibition and the in vitro inhibition of cytochrome P450 3A4 (CYP3A4) isoezyme by selected wild edible plants to identify potential food/herb-drug interactions.en
dc.description.sponsorshipSelfen
dc.identifier.urihttps://hdl.handle.net/20.500.14155/2148
dc.language.isoenen
dc.publisherElsevieren
dc.subjectp-glycoprotein, cytochrome P450 3A4 isoenzyme, microsomes, porcine intestinal tissue, wild edible plantsen
dc.titleEvaluation of Southern African Wild Edible Plants for Potential Herb-Drug Interactions Through Ex Vivo P-Glycoprotein and In Vitro Cytochrome P450 3A4 Inhibitory Effectsen
dc.typeArticleen
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